Giovanni di Bicci de' Medici was an Italian banker and founder of the Medici Bank. While other members of the Medici family, such as Chiarissimo di Giambuono de' Medici, who served in the Signoria of Florence in 1401, and Salvestro de' Medici, who was implicated in the Ciompi Revolt of 1378, are of historical interest, it was Giovanni's founding of the family bank that truly initiated the family's rise to power in Florence. He was the father of Cosimo de' Medici and of Lorenzo the Elder; grandfather of Piero di Cosimo de' Medici; great-grandfather of Lorenzo de' Medici ; and the great-great-great-grandfather of Cosimo I de' Medici, Grand Duke of Tuscany.

Cosimo I de' Medici was the second duke of Florence from 1537 until 1569, when he became the first grand duke of Tuscany, a title he held until his death.