Gjon II Kastrioti, was the son of Gjergj Kastrioti Skanderbeg, the Albanian national hero, and of Donika Kastrioti, daughter of the powerful Albanian prince, Gjergj Arianiti. He was for a short time Lord of Kruja after his father's death, then Duke of San Pietro in Galatina (1485), Count of Soleto, Signore of Monte Sant'Angelo and San Giovanni Rotondo. In 1495, Ferdinand I of Naples gave him the title of the Signore of Gagliano del Capo and Oria. While in his teens, he was forced to leave the country after the death of his father in 1468. He is known also for his role in the Albanian Uprisings of 1481, when, after reaching the Albanian coast from Italy, settling in Himara, he led a rebellion against the Ottomans. In June 1481, he supported forces of Ivan Crnojević to successfully recapture Zeta from the Ottomans. He was unable to re-establish the Kastrioti Principality and liberate Albania from the Ottomans, and he retired in Italy after three years of war in 1484.

Gjergj Kastrioti, commonly known as Skanderbeg, was an Albanian feudal lord and military commander who led a rebellion against the Ottoman Empire in what is today Albania, North Macedonia, Greece, Kosovo, Montenegro, and Serbia.