In mathematical physics, Gleason's theorem shows that the rule one uses to calculate probabilities in quantum physics, the Born rule, can be derived from the usual mathematical representation of measurements in quantum physics together with the assumption of non-contextuality. Andrew M. Gleason first proved the theorem in 1957, answering a question posed by George W. Mackey, an accomplishment that was historically significant for the role it played in showing that wide classes of hidden-variable theories are inconsistent with quantum physics. Multiple variations have been proven in the years since. Gleason's theorem is of particular importance for the field of quantum logic and its attempt to find a minimal set of mathematical axioms for quantum theory.

Andrew Mattei Gleason (1921–2008) was an American mathematician who made fundamental contributions to widely varied areas of mathematics, including the solution of Hilbert's fifth problem, and was a leader in reform and innovation in math­e­mat­ics teaching at all levels. Gleason's theorem in quantum logic and the Greenwood–Gleason graph, an important example in Ramsey theory, are named for him.