Glenville High School is a public high school in the Glenville area on the East Side of Cleveland, Ohio. The school is part of the Cleveland Metropolitan School District. The school originally resided at the former Oliver Wendell Holmes school which formerly sat on the northeast corner of E. 105th and St. Clair then later moved to Parkwood and Everton in October 1904 as population grew. The current building was built in 1964 and is located at E. 113th and St. Clair.

Glenville is a neighborhood on the East Side of Cleveland, Ohio. To the north, it borders the streetcar suburb of Bratenahl, the Cleveland Memorial Shoreway, and the Lake Erie shore, encompassing the Cleveland Lakefront Nature Preserve. To the east, it borders the suburb of East Cleveland, and to the south, it borders the neighborhoods of Hough and University Circle. Glenville borders the Collinwood area to the northeast at East 134th Street, and St. Clair–Superior to the west at Martin Luther King Jr. Boulevard and the Cleveland Cultural Gardens in Rockefeller Park.