A glovebox is a sealed container that is designed to allow one to manipulate objects where a separate atmosphere is desired. Built into the sides of the glovebox are gloves arranged in such a way that the user can place their hands into the gloves and perform tasks inside the box without breaking containment. Part or all of the box is usually transparent to allow the user to see what is being manipulated. Two types of gloveboxes exist. The first allows a person to work with hazardous substances, such as radioactive materials or infectious disease agents, and the second allows manipulation of substances that must be contained within a very high purity inert atmosphere, such as argon or nitrogen. It is also possible to use a glovebox for manipulation of items in a vacuum chamber.

The Rocky Flats Plant was a U.S. manufacturing complex that produced nuclear weapons parts in the western United States, near Denver, Colorado. The facility's primary mission was the fabrication of plutonium pits, which were shipped to other facilities to be assembled into nuclear weapons. Operated from 1952 to 1992, the complex was under the control of the U.S. Atomic Energy Commission (AEC), succeeded by the Department of Energy (DOE) in 1977.