Glucokinase
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Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. In medicine, the term is often used to refer to a specific hexokinase found in vertebrates and coded by the
Structures of Escherichia coli ATP-dependent glucokinase.
1v4s: Crystal structure of human glucokinase
1v4t: Crystal structure of human glucokinase
Insulin
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Insulin is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin gene. It is the main anabolic hormone of the body. It regulates the metabolism of carbohyd
Glucokinase
…Glucokinase is not inhibited by physiological concentrations of its product, glucose-6-phosphate. This allows continued signal output (e.g., to trigger insulin release) amid significant amounts of its product. Another distinctive property of glucokinase is its moderate cooperativity with glucose, with a Hill…
The structure of insulin. The left side is a space-filling model of the insulin monomer, believed to be biologically active. Carbon is green, hydrogen white, oxygen red, and nitrogen blue. On the right side is a ribbon diagram of the insulin hexamer, believed to be the stored form. A monomer unit is highlighted with the A chain in blue and the B chain in cyan. Yellow denotes disulfide bonds, and magenta spheres are zinc ions.
Two vials of insulin. They have been given trade names, Actrapid (left) and NovoRapid (right) by the manufacturers.
Charles Best and Clark Noble ca. 1920
Chart for Elizabeth Hughes, used to track blood, urine, diet in grams, and dietary prescriptions in grams