Gnadenhutten is a village located on the Tuscarawas River in Tuscarawas County, Ohio, United States. The population was 1,240 at the 2020 census. It is Ohio's oldest existing settlement, being founded by Moravian Christians in 1772 and was the site of the Gnadenhutten massacre during the American Revolutionary War. It is part of the New Philadelphia–Dover micropolitan area.

The Tuscarawas River is a principal tributary of the Muskingum River, 129.9 miles (209 km) long, in northeastern Ohio in the United States. Via the Muskingum and Ohio rivers, it is part of the watershed of the Mississippi River, draining an area of 2,590 square miles (6,700 km2) on glaciated and unglaciated portions of the Allegheny Plateau.