Gnatia, Egnatia or Ignatia was an ancient city of the Messapii, and their frontier town towards the Salentini. As Egnazia Appula, it was a medieval bishopric, which remains a Latin Catholic titular see.

The Messapians were an Iapygian tribe who inhabited Salento in classical antiquity. Two other Iapygian tribes, the Peucetians and the Daunians, inhabited central and northern Apulia respectively. All three tribes spoke the Messapian language, but had developed separate archaeological cultures by the seventh century BC. The Messapians lived in the eponymous region Messapia, which extended from Leuca in the southeast to Kailia and Egnatia in the northwest, covering most of the Salento peninsula. This region includes the Province of Lecce and parts of the provinces of Brindisi and Taranto today.