The Golden Melody Award for Best Female Mandarin Singer is a Golden Melody Award recognizing outstanding vocal performance by a female in the Mandopop category, the first of which was presented in 1991.

Jolin Tsai is a Taiwanese singer, songwriter, and actress. Known as the "Queen of C-pop", she is one of the most influential pop cultural figures in the Chinese-speaking world. Recognized for her continual reinvention and versatility in musical style and visual image, she is regarded as a key figure in bringing dance-pop music into the mainstream in Greater China. She assumes creative control over all aspects of her career, and her works, which incorporate themes of societal issues and ideological connotations, have garnered both commercial success and critical acclaim.