Goose Creek is the most populous city in Berkeley County in the U.S. state of South Carolina. The population was 45,946 at the 2020 census, making it the 7th-most populous city in the state. Most of the Naval Weapons Station Charleston is in Goose Creek. As defined by the U.S. Office of Management and Budget, and used only by the U.S. Census Bureau and other federal agencies for statistical purposes, Goose Creek is included within the Charleston-North Charleston, SC Metropolitan Statistical Area.

Berkeley County is a county in the U.S. state of South Carolina. As of the 2020 census, its population was 229,861. Its county seat is Moncks Corner, and the largest community is Goose Creek. After two previous incarnations of Berkeley County, the current county was created in 1882. Berkeley County is included in the Charleston-North Charleston, SC Metropolitan Statistical Area.