The Gottardo was an express train that, for most of its existence, linked Zurich, Switzerland, with Milan, Italy. Introduced in 1961, it was a first-class-only Trans Europ Express (TEE) until 1988, then becoming a EuroCity service and finally a EuroNight service – on a longer route, to Rome – before being discontinued in 2002. The train followed the Gotthard railway and was named for the line, using the Italian spelling for it, Ferrovia del Gottardo.

The Gotthard railway is the Swiss trans-alpine railway line from northern Switzerland to the canton of Ticino. The line forms a major part of an important international railway link between northern and southern Europe, especially on the Rotterdam-Basel-Genoa corridor. The Gotthard Railway Company was the former private railway company that financed the construction of and originally operated that line.