The government of the City and County of San Francisco utilizes the "strong mayor" form of mayoral/council government, composed of the Mayor, Board of Supervisors, several elected officers, and numerous other entities. It is the only consolidated city-county in California, and one of only thirteen charter counties of California. The fiscal year 2019–20 city and county budget was approximately $12.3 billion.

The mayor of the City and County of San Francisco is the head of the executive branch of the San Francisco city and county government. The officeholder has the duty to enforce city laws, and the power to either approve or veto bills passed by the San Francisco Board of Supervisors, the legislative branch. The mayor serves a four-year term and is limited to two successive terms. Because of San Francisco's status as a consolidated city-county, the mayor also serves as the head of government of the county; both entities have been governed together by a combined set of governing bodies since 1856.