The governor of Tlaxcala is the position representing the complete executive power of the government of the Mexican state of Tlaxcala, per the Political Constitution of the Free and Sovereign State of Tlaxcala.

Lorena Cuéllar Cisneros is a Mexican politician affiliated with the National Regeneration Movement (MORENA) who serves as the Governor of Tlaxcala. Formerly she served as a member of the Labor Party (PT) as a federal deputy in the LXIV Legislature of the Mexican Congress representing Tlaxcala; she had previously been a senator and mayor of the state capital of Tlaxcala.