Graaff-Reinet is a town in the Eastern Cape Province of South Africa. It is the oldest town in the province and the fourth oldest town in South Africa, after Cape Town, Stellenbosch, Simon's Town, Paarl and Swellendam. The town was the centre of a short-lived republic in the late 18th century. The town was a starting point for Great Trek groups led by Gerrit Maritz and Piet Retief and furnished large numbers of the Voortrekkers in 1835–1842.

The Eastern Cape is one of the nine provinces of South Africa. Its capital is Bhisho, but its two largest cities are East London and Gqeberha. Due to its climate and nineteenth century towns, it is a common location for tourists. It is also known for being home to many anti-apartheid activists, the most famous being Nelson Mandela hailing from the province.