Graduate student employee unionization, or academic student employee unionization, refers to labor unions that represent students who are employed by their college or university to teach classes, conduct research and perform clerical duties. As of 2014, there were at least 33 US graduate employee unions, 18 unrecognized unions in the United States, and 23 graduate employee unions in Canada. By 2019, it is estimated that there were 83,050 unionized student employees in certified bargaining units in the United States. As of 2023, there were at least 156 US graduate student employee unions and 23 graduate student employee unions in Canada.

The Teaching Assistants Association (TAA) is a graduate student employee union formed at the University of Wisconsin–Madison in 1966. It is credited as the first graduate student labor union. Following voluntary recognition by the university as the teaching assistants' bargaining agent in 1969, negotiations resulted in a 1970 strike, which secured "bread-and-butter" gains such as job security alongside grievance procedures. Their major unmet demand from their strike—the inclusion of teaching assistants and students in the course planning process—went unfulfilled. The TAA struck again in 1980 and lost its union recognition until 1986. The union's protest at the Wisconsin State Capitol building began the 2011 Wisconsin protests.