Graham's Magazine was a nineteenth-century periodical based in Philadelphia established by George Rex Graham and published from 1840 to 1858. It was alternatively referred to as Graham's Lady's and Gentleman's Magazine, Graham's Magazine of Literature and Art, Graham's American Monthly Magazine of Literature and Art, and Graham's Illustrated Magazine of Literature, Romance, Art, and Fashion.

George Rex Graham was an American magazine editor and publisher from Philadelphia, Pennsylvania. He founded the journal Graham's Magazine at the age of 27 after buying Burton's Gentleman's Magazine and Atkinson's Casket. His journal became very popular and it was known for its generous payment to contributors.