The Grand Central Art Galleries were the exhibition and administrative space of the nonprofit Painters and Sculptors Gallery Association, an artists' cooperative established in 1922 by Walter Leighton Clark together with John Singer Sargent, Edmund Greacen, and others. Artists closely associated with the Grand Central Art Galleries included Hovsep Pushman, George de Forest Brush, and especially Sargent, whose posthumous show took place there in 1928.

John Singer Sargent was an American expatriate artist, considered the "leading portrait painter of his generation" for his evocations of Edwardian-era luxury. He created roughly 900 oil paintings and more than 2,000 watercolors, as well as countless sketches and charcoal drawings. His oeuvre documents worldwide travel, from Venice to the Tyrol, Corfu, Spain, the Middle East, Montana, Maine, and Florida.