The Grand Chancellor of Lithuania was one of the highest offices in the Grand Duchy of Lithuania. The office functioned from the middle of the 15th century until the end of the real union with the Kingdom of Poland in 1795 and its subsequent partition among Prussia, Russia and Austria. The chancellor possessed the Great Seal of Lithuania and had the Lithuanian Metrica at his disposal.

The prime minister of Lithuania is the head of the government of Lithuania. The prime minister is Lithuania's head of government and is appointed by the president with the assent of the Lithuanian parliament, the Seimas. The modern office of prime minister was established in 1990, when Lithuania declared its independence, although the official title was "Chairperson of the Council of Ministers" until 25 November 1992.