The Grand Combin is a mountain massif in the western Pennine Alps in the canton of Valais. At a height of 4,309 metres (14,137 ft) the summit of Combin de Grafeneire is one of the highest peaks in the Alps and the second most prominent of the Pennine Alps. The Grand Combin is also a large glaciated massif consisting of several summits, among which three are above 4000 metres. The highest part of the massif is wholly in Switzerland, although the border with Italy lies a few kilometres south.

The Pennine Alps French: Alpes Pennines, German: Walliser Alpen, Italian: Alpi Pennine, Latin: Alpes Poeninae), sometimes referred to as the Valais Alps, are a mountain range in the western part of the Alps. They are located in Italy and Switzerland (Valais).