The Grand Hotel International Prague is a four-star hotel located in the Dejvice quarter of Prague, in the Czech Republic. It was completed in 1956 in the socialist realism style, and is a Czech cultural monument. The hotel has retained much of its original interior artwork, contains 278 guest rooms, and was originally designed as a military hotel before public use as a luxury hotel. It has previously operated under the names Hotel Družba, Hotel Čedok, Hotel Holiday Inn and Hotel Crowne Plaza.

Dejvice is a historical community, a municipal quarter of the Prague 6 district of Prague, Czech Republic. Its history can be traced back to the late Roman era. Dejvice is known for its appeal to the upper middle class, foreign diplomatic corps and as a university district. It is also the home to Dukla Prague, one of the most successful football clubs of the Czechoslovak era.