Grand Lisboa is a 47-floor, 261-metre-tall (856 ft) hotel in Sé, Macau. It is owned by Sociedade de Turismo e Diversões de Macau and designed by Hong Kong architects Dennis Lau and Ng Chun Man with the interiors created by Khuan Chew, Design Principal of KCA International. Its casino and restaurants were opened on February 11, 2007, while the hotel was opened in December 2008. The casino offers 800 gaming tables and 1,000 slot machines. The hotel contains 430 hotel rooms and suites. The Grand Lisboa is the tallest building in Macau and the most distinctive part of its skyline.

Gambling in Macau has been legal since the 1850s when the Portuguese government legalised the activity in the autonomous colony. Since then, Macau has become known worldwide as the "Gambling capital of the world". It is the only place in China where casino gambling is legal.