Grand Saline is a city in Van Zandt County, Texas, United States, located in East Texas. The population was 3,107 as of 2020, making Grand Saline the third-largest city in Van Zandt County. The city is located roughly 75 miles (120 km) east of Dallas and 35 miles (56 km) northwest of Tyler, the two nearest metropolitan areas, and is part of the greater Tyler/Longview area.

Van Zandt County is a county located in the U.S. state of Texas, in the northeastern part of the state. As of the 2020 census, its population was 59,541. Its county seat is Canton. The county is named for Isaac Van Zandt (1813–1847), a member of the Congress of the Republic of Texas.