Grand Valley is an American Viticultural Area (AVA) within Mesa County, Colorado located in a high-altitude river valley surrounding the county seat of Grand Junction and stretching 24 miles (39 km) east-west between the municipalities of Palisade and Fruita. It lies approximately 200 miles (320 km) west-southwest of Denver along Interstate 70. The river valley encompasses 75,990 acres (118.73 sq mi), with an average elevation between 4,000 and 5,000 feet (1,200–1,500 m) above sea level and is defined by an irrigated agricultural area served by canals in the Grand Valley of the Colorado River. Grand Valley AVA was established by the Bureau of Alcohol, Tobacco and Firearms (ATF) on December 26, 1991, upon the petition submitted by Mr. James Seewald of Vintage Colorado Cellars Winery, and was the first viticultural area registered in Colorado. In 2001, the smaller West Elks AVA, located southeast of Grand Valley, became the state's second federally-designated AVA.

Mesa County is a county located in the U.S. state of Colorado. As of the 2020 census, the population was 155,703. The county seat and most populous municipality is Grand Junction. The county was named for the many large mesas in the area, including the Grand Mesa, which is the largest flat-topped mountain in the world.