Grayson is a city in Gwinnett County, Georgia, United States. The 2020 estimated population of Grayson, GA is 4740 people. The population was 2,666 at the 2010 census, up from 765 in 2000.

State Route 20 (SR 20) is a 165.345-mile-long (266.097 km) state highway roughly in the shape of a capital J rotated ninety degrees to the left, which travels through portions of Floyd, Bartow, Cherokee, Forsyth, Gwinnett, Walton, Rockdale, Newton, and Henry counties in the northwestern and north-central parts of the U.S. state of Georgia. Its counterclockwise, or western terminus is at the Alabama state line in Floyd County, and its clockwise, or eastern terminus occurs at its interchange with Lower Woolsey Road southwest of Hampton in Henry County south-southeast of the Atlanta Motor Speedway.