Grayville is a city in Edwards and White counties in the U.S. state of Illinois. As of the 2020 census, the city's population was 1,550, down from 1,666 at the 2010 census. Grayville is the birthplace of naval hero James Meredith Helm.

Illinois Route 1 (IL 1) is a state highway in the U.S. state of Illinois. Running parallel to the Indiana border, the highway starts at the free ferry crossing to Kentucky at Cave-in-Rock on the Ohio River and runs north to the south side of Chicago as Halsted Street at an intersection with Interstate 57. This is a distance of 325.59 miles (523.99 km).