The Great Central Railway in England was formed when the Manchester, Sheffield and Lincolnshire Railway changed its name in 1897, anticipating the opening in 1899 of its London Extension. On 1 January 1923, the company was grouped into the London and North Eastern Railway.

The Manchester, Sheffield and Lincolnshire Railway (MS&LR) was formed in 1847 when the Sheffield, Ashton-under-Lyne and Manchester Railway joined with authorised but unbuilt railway companies, forming a proposed network from Manchester to Grimsby. It pursued a policy of expanding its area of influence, especially in reaching west to Liverpool, which it ultimately did through the medium of the Cheshire Lines Committee network in joint partnership with the Great Northern Railway and the Midland Railway.