The Great Colonnade at Apamea was the main colonnaded avenue of the ancient city of Apamea in the Orontes River valley in northwestern Syria. It was built in the second century CE after Apamea's devastation in the 115 earthquake. The avenue, which runs for nearly 2 kilometres (1.2 mi), made up the city's north-south axis, or the cardo maximus. The monumental colonnade is among the longest and most famous in the Roman world.

Apamea, on the right bank of the Orontes River, was an ancient Greek and Roman city. It was the capital of Apamene under the Macedonians, became the capital and Metropolitan Archbishopric of late Roman province Syria Secunda, again in the crusader period.