The Great Debate, also called the Shapley–Curtis Debate, was held on 26 April 1920 at the Smithsonian Museum of Natural History, between the astronomers Harlow Shapley and Heber Curtis. It concerned the nature of so-called spiral nebulae and the size of the universe. Shapley believed that these nebulae were relatively small and lay within the outskirts of the Milky Way galaxy, while Curtis held that they were in fact independent galaxies, implying that they were exceedingly large and distant.

The National Museum of Natural History (NMNH) is a natural history museum administered by the Smithsonian Institution, located on the National Mall in Washington, D.C., United States. It has free admission and is open 364 days a year. With 4.4 million visitors in 2023, it was the second most-visited museum in the United States.