The Great Divide Basin or Great Divide Closed Basin is an area of land in the Red Desert of Wyoming where none of the water falling as rain to the ground drains into any ocean, directly or indirectly. It is thus an endorheic basin, one of several in North America that adjoin the Continental Divide. To the south and west of the basin is the Green River watershed, draining to the Gulf of California/Pacific Ocean; to the north and east is the North Platte watershed, draining to the Gulf of Mexico. The basin is very roughly rectangular in shape; the northwest corner is at Oregon Buttes near South Pass, about 40 miles (64 km) southwest of Lander, and the southeast corner is in the Sierra Madre Range near Bridger Pass, about 20 miles (32 km) southwest of Rawlins.

The Continental Divide of the Americas is the principal, and largely mountainous, hydrological divide of the Americas. The Continental Divide extends from the Bering Strait to the Strait of Magellan, and separates the watersheds that drain into the Pacific Ocean from those river systems that drain into the Atlantic and Arctic Ocean, including those that drain into the Gulf of Mexico, the Caribbean Sea, and Hudson Bay.