The Great Mosque of Kilwa is a congregational mosque on the island of Kilwa Kisiwani, in Kilwa Masoko in Kilwa District in Lindi Region of Tanzania. It was likely founded in the tenth century, but the two major stages of construction date to the eleventh or twelfth and thirteenth century, respectively. It is one of the earliest surviving mosques on the Swahili coast and is one of the first mosques built without a courtyard.

Kilwa Kisiwani is an island, national historic site, and hamlet community located in the township of Kilwa Masoko, the district seat of Kilwa District in the Tanzanian region of Lindi in southern Tanzania. Kilwa Kisiwani is the largest of the nine hamlets in the town of Kilwa Masoko and is also the least populated hamlet in the township with fewer than 1,000 residents.