Great Mosque of Nablus is the oldest and largest mosque in the Palestinian city of Nablus. It was originally built as a Byzantine church and was converted into a mosque during the early Islamic era. The Crusaders transformed it into a church in the 11th century, but it was reconsecrated as a mosque by the Ayyubids in the 12th century. The mosque is located at the intersection of the main streets of the Old City, along the district's eastern edges. It has a long, narrow, rectangular floor plan and a silver dome.

Nablus is a Palestinian city in the West Bank, located approximately 49 kilometres (30 mi) north of Jerusalem, with a population of 156,906. Located between Mount Ebal and Mount Gerizim, it is the capital of the Nablus Governorate and a commercial and cultural centre of the State of Palestine, home to An-Najah National University, one of the largest Palestinian institutions of higher learning, and the Palestine Stock Exchange. Nablus is under the administration of the Palestinian National Authority (PNA).