Great Northern Highway is an Australian highway that links Western Australia's capital city Perth with its northernmost port, Wyndham. With a length of almost 3,200 kilometres (2,000 mi), it is the longest highway in Australia, with the majority included as part of the Perth Darwin National Highway. The highway, which travels through remote areas of the state, is constructed as a sealed, predominantly two-lane single carriageway, but with some single-lane bridges in the Kimberley. Economically, it provides vital access through the Wheatbelt and Mid West to the resource-rich regions of the Pilbara and Kimberley. In these areas, the key industries of mining, agriculture and pastoral stations, and tourism are all dependent on the highway.

Wyndham is the northernmost town in the Kimberley region of Western Australia, 3,315 kilometres (2,060 mi) northeast of Perth via the Great Northern Highway. It was established in 1886 to service a new goldfield at Halls Creek, and it is now a port and service centre for the east Kimberley with a population of 941 as of the 2021 census. Aboriginal and Torres Strait Islander people make up 54% of the population. Wyndham comprises two areas - the original town site at Wyndham Port situated on Cambridge Gulf, and 5 kilometres (3.1 mi) by road to the south, the Three Mile area with the residential and shopping area for the port, also founded in 1886. Wyndham is part of the Shire of Wyndham-East Kimberley.