The Great Plague of London, lasting from 1665 to 1666, was the most recent major epidemic of the bubonic plague to occur in England. It happened within the centuries-long Second Pandemic, a period of
Collecting the dead for burial during the Great Plague
Rattus rattus, the black rat. Smaller than Rattus norvegicus, the brown rat, which later supplanted it, it is also keener to live near humankind. Timber houses and overcrowded slums provided excellent homes. The link between the rat as reservoir of infection and host to fleas which could transfer to man was not understood. Efforts were made to eliminate cats and dogs: if anything, this encouraged the rats. Body lice were also important plague vectors.
Two men discovering a dead woman in the street
Scenes in London during the plague
The Black Death was a plague pandemic that occurred in Europe from 1346 to 1353. It was one of the most fatal pandemics in human history, leading to the death of up to 50 million people, around 30% to
Great Plague of London
…the centuries-long Second Pandemic, a period of intermittent bubonic plague epidemics that originated in Central Asia in 1331 (the first year of the Black Death), and included related diseases such as pneumonic plague and septicemic plague, which lasted until 1750. The Great Plague killed an estimated 100,000…
Yersinia pestis (200 × magnification), the bacterium that causes plague
The Oriental rat flea (Xenopsylla cheopis) engorged with blood. This species of flea is the primary vector for the transmission of Yersinia pestis, the organism responsible for spreading bubonic plague in most plague epidemics. Both male and female fleas feed on blood and can transmit the infection.
Oriental rat flea (Xenopsylla cheopis) infected with the Yersinia pestis bacterium which appears as a dark mass in the gut. The foregut (proventriculus) of this flea is blocked by a Y. pestis biofilm; when the flea feeds on an uninfected host Y. pestis is regurgitated into the wound, causing infection.
Skeletons in a mass grave from 1720 to 1721 in Martigues, near Marseille in southern France, yielded molecular evidence of the orientalis strain of Yersinia pestis, the organism responsible for bubonic plague. The second pandemic of bubonic plague was active in Europe from 1347, the beginning of the Black Death, until 1750.