The Great Plains Indian trading networks encountered by the first Europeans on the Great Plains were built on a number of trading centers acting as hubs in an advanced system of exchange over great distances. The primary centers were found at the villages of the Mandan, Hidatsa, and Arikara, with a surplus of agricultural produce that could be exchanged. Secondary centers were found at the villages of the Pawnee, Kansa, and Osage on the central great plains, and at the Caddo villages on the southern plains. The Dakota rendezvous was an important annual trading fair among the Sioux. European demand for fur changed the relations of the plains, increased the occurrence of war, and displaced several Indian nations that were forced away by the Sioux coming from the east. On the northern plains, European trade lay in the hands of the Hudson's Bay Company, although most of the territory belonged to France, and later Spain. European trade on the central plains was controlled by French merchants, first from New Orleans, later from St. Louis. From the mid-1700s', the Comanche became an increasingly important military and commercial factor on the southern plains, forcing the Apaches into the mountains, and exchanging goods and spoils with the Southwestern trading networks hubs in New Mexico.

The Osage Nation is a Midwestern American tribe of the Great Plains. The tribe developed in the Ohio and Mississippi river valleys around 700 B.C. along with other groups of its language family. They migrated west after the 17th century, settling near the confluence of the Missouri and Mississippi rivers, as a result of Iroquois expansion into the Ohio Country in the aftermath of the Beaver Wars.