The Great Pyramid of Cholula, also known as Tlachihualtepetl, is a complex located in Cholula, Puebla, Mexico. It is the largest archaeological site of a pyramid (temple) in the world, as well as the largest pyramid by volume known to exist in the world today. The adobe brick pyramid stands 25 metres (82 ft) above the surrounding plain, which is significantly shorter than the Great Pyramid of Giza's height of 146.6 metres (481 ft), but much wider, measuring 300 by 315 metres in its final form, compared to the Great Pyramid's base dimensions of 230.3 by 230.3 metres. The pyramid is a temple that traditionally has been viewed as having been dedicated to the god Quetzalcoatl. The architectural style of the building was linked closely to that of Teotihuacan in the Valley of Mexico, although influence from the Gulf Coast is evident as well, especially from El Tajín.

Mesoamerican pyramids form a prominent part of ancient Mesoamerican architecture. Although similar in some ways to Egyptian pyramids, these New World structures have flat tops and stairs ascending their faces, more similar to ancient Mesopotamian Ziggurats. The largest pyramid in the world by volume is the Great Pyramid of Cholula, in the east-central Mexican state of Puebla. The builders of certain classic Mesoamerican pyramids have decorated them copiously with stories about the Hero Twins, the feathered serpent Quetzalcoatl, Mesoamerican creation myths, ritualistic sacrifice, etc. written in the form of Maya script on the rises of the steps of the pyramids, on the walls, and on the sculptures contained within.