The Great Smoky Mountains Railroad is a heritage and freight railroad based in Bryson City, North Carolina, United States. Originally formed in 1988, it was currently owned and operated by American Heritage Railways since late 1999. The GSMR operates excursion trains on the former Southern Railway's Murphy Branch between Dillsboro and Nantahala, North Carolina. The GSMR is one of the most popular tourist railroads in the United States, carrying 200,000 passengers each year.

Bryson City is a town in and the county seat of Swain County, North Carolina, United States. The population was 1,558 as of the 2020 census. Located in what was historically the land of the Cherokee, Bryson City was founded as Charleston to serve as the county seat of Swain County when it was formed from parts of surrounding counties. It grew into an important local rail hub. Today the city serves as a popular tourist destination, lying just to the west of the entrance to the Great Smoky Mountains National Park, for outdoor activities in the Nantahala National Forest, and along the Nantahala River and Fontana Lake, and serves as the home of the Great Smoky Mountains Railroad, a heritage railroad that provides tours of the Nantahala valley. The popular Nantahala Outdoor Center provides guide services for many of the outdoor activities in the area.