The Great Southern wine region is in Western Australia's Great Southern region. It comprises an area 200 kilometres (120 mi) from east to west and over 100 kilometres (62 mi) from north to south, and is Australia's largest wine region.

The Great Southern region is one of the nine regions of Western Australia, as defined by the Regional Development Commissions Act 1993, for the purposes of economic development. It is a section of the larger south coast of Western Australia and neighbouring agricultural regions.