Green Cove Springs is a city in and the county seat of Clay County, Florida, United States. Green Cove Springs is a part of the Jacksonville metropolitan area. The population was 9,786 at the 2020 census.

State Road 16 (SR 16) runs from northwest to southeast between Raiford and St. Augustine. It passes through the towns of Starke and Green Cove Springs in addition to providing access to Camp Blanding. Major roads and/or highways that SR 16 crosses include: US 301, SR 21, US 17, SR 13, Interstate 95 and US 1.