Royal Air Force Hutton Cranswick or more RAF Hutton Cranswick is a former Royal Air Force station located to the south of Driffield and south west of the village of Hutton Cranswick in the East Riding of Yorkshire, opened in 1942 and closed in 1946. RAF Hutton Cranswick opened in January 1942 as a fighter airfield within No. 12 Group RAF. Unusually for the time its three runways were concrete "from new", many airfields were built with grass runways which were upgraded to concrete. Many squadrons rotated through the airfield including 610, 19, 308, 316, 195, 306, 302, 315, 234, 168 and No. 170 Squadron RAF. From December 1943 the Anti Aircraft Co-operation 291 Squadron was formed at the airfield for target towing and similar uses. Whilst in use by 291 other fighter squadrons continued to rotate through including 401, 403, 412, 441, 442, 443 and 439 using Hawker Typhoons; the final unit to operate from Hutton Cranswick was No. 124 Squadron RAF using Spitfire IXs. Hutton Cranswick was used by No. 16 Armament Practice Camp RAF for about a year until it closed in mid 1946.

A number of other units used the airfield: No. 2 Operational Training Unit RAF No. 2 Tactical Exercise Unit RAF No. 4 Aircraft Delivery Flight RAF No. 6 Anti-Aircraft Co-operation Unit RAF No. 8 Fighter Command Servicing Unit RAF No. 13 Fighter Command Servicing Unit RAF No. 123 Airfield 885 Naval Air Squadron No. 1489 Gunnery Flight RAF No. 1495 Flight RAF No. 1613 Flight RAF No. 1629 Flight RAF No. 1634 Flight RAF No. 2731 Squadron RAF Regiment No. 2739 Squadron RAF Regiment No. 2805 Squadron RAF Regiment The site is now used for farming and light industrial work

The Marthoma Nazrani Eparchy of Idukki is a suffragan eparchy in southern India, in the proper ecclesiastical province of the Major Archdiocese of Eranakulam-Angamaly, which heads the entire Syro-Malabar Catholic Church, hence dependent on the Roman Congregation for the Oriental Churches. Its cathedral episcopal see is Saint George's Cathedral Vazhathoppe, in Idukki township, in Kerala state; the creation of the diocese on 2003.01.15, as the twenty-sixth eparchy of the Syro-Malabar Catholic Church, on territory split off from the Major Archdiocese of Ernakulam–Angamaly is contained in an Apostolic Constitution Maturescens catholica fideis put forth by Pope John Paul II in December 2002. It started with mission stations; as per 2015, it pastorally served 266,600 Catholics on 3,000 km² in 155 parishes with 573 priests, 1,306 lay religious and 86 seminarians. Suffragan Eparchs of IdukkiFirst Bishop Avoon Mar Mathew Anikuzhikattil, originated from the diocese of Kothamangalam Present Avoon Mar John Nellikunnel.

GCatholic, with Google HQ satellite picture - data for all sections official diocesan website, with map, diocesan chronicle etc. Archdiocese of Ernakulam Catholic-Hierarchy

The mobilized colistin resistance gene confers plasmid-mediated resistance to colistin, one of a number of last-resort antibiotics for treating Gram-negative infections. Mcr-1, the original variant, is capable of horizontal transfer between different strains of a bacterial species. After discovery in November 2015 in E. coli from a pig in China it has been found in Escherichia coli, Salmonella enterica, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae. As of 2017, it has been detected in more than 30 countries on 5 continents in less than a year; the "mobilized colistin resistance" gene confers plasmid-mediated resistance to colistin, a polymyxin and one of a number of last-resort antibiotics for treating infections. The gene is found in no less than ten species of the Enterobacteriaceae: Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, Cronobacter sakazakii, Shigella sonnei, Kluyvera species, Citrobacter species, Raoultella ornithinolytica.

The mechanism of resistance of the MCR gene is a phosphatidylethanolamine transferase. The enzyme transfers a phosphoethanolamine residue to the lipid A present in the cell membrane of gram-negative bacteria; the altered lipid A has much lower affinity for colistin and related polymyxins resulting in reduced activity of the antimicrobial. This type of resistance is known as target modification. Although the same mechanism has been observed before with enzymes like eptA, mcr-1 is the first polymyxin resistance gene known to be capable of horizontal transfer between different strains of a bacterial species; the gene was first discovered in E. coli from a pig in China April 2011 and published in November 2015. It was identified by independent researchers in human samples from Malaysia, England and the United States. In April 2016, a 49-year-old woman sought medical care at a Pennsylvania clinic for UTI symptoms. PCR of an E. coli isolate cultured from her urine revealed the mcr-1 gene for the first time in the United States, the CDC sent an alert to health care facilities.

In the following twelve months, four additional people were reported to have infections with mcr-1 carrying bacteria. As of February 2017 mcr-1 has been detected in more than 30 countries on 5 continents in less than a year, it appears to be spreading in hospitals in China; the prevalence in five Chinese provinces between April 2011 and November 2014 was 15% in raw meat samples and 21% in food animals during 2011–14, 1% in people hospitalized with infection. Using genetic analysis, researchers believe that they have shown that the origins of the gene were on a Chinese pig farm where colistin was used. Given the importance of mcr-1 in enabling bacteria to acquire polymyxin resistance, MCR-1 is a current inhibition target for the development of new antibiotics. For example, ethylenediaminetetraacetic acid, a metal-chelating agent, was shown to inhibit MCR-1 as it is a zinc-dependent enzyme. Substrate analogues, such as ethanolamine and glucose, were shown to inhibit MCR-1; the use of a combined antibiotics regime has shown to be able to overcome the resistance, caused by mcr-1, although the mechanism of action may not be directly targeting the MCR-1 protein.

As of May 2019, nine mobilized colistin resistance genes termed mcr-1 through mcr-9 has been identified. They are homologous to each other, work in similar ways; the mcr-2 gene is found only in Belgium. The less-related mcr-3, mcr-4, mcr-5 were identified in E. coli and Salmonella. On the phylogenic tree, the various clusters of mcr genes are scattered between immobile resistance genes of the same type, suggesting a history of multiple transfer to plasmids. New Delhi metallo-beta-lactamase 1

The Siege of Sozopolis saw the Byzantine conquest of the Seljuq Turk-held town of Sozopolis in 1120, improving Byzantine communications with the city of Attaleia. After re-conquering the city of Laodicea from a Seljuq Turkish garrison of 700 men in 1119, the Byzantine emperor John II Komnenos continued his campaigns against the Turks in 1120 after a brief stay in Constantinople; the 1120 campaign target was the town of Sozopolis in Pisidia, which controlled the lines of communication to Attaleia. Sozopolis was protected by steep hills. A large-scale siege attack was thus impossible; the town could only be attacked by small forces. John was at a loss how to proceed but came up with a plan, he ordered a force of missile-armed armed cavalry under Paktiarios and Dekanos to attack the town gates and shoot at the Turkish soldiers manning the walls. The Turks poured out of the gate; the Byzantine force executed a planned retreat, drawing the Turks far out beyond the town. The rest of the Byzantine army had lain hidden in the thick undergrowth and assaulted the undefended town after the Turks had passed them.

The fleeing Byzantines faced the pursuing Turks. The Turks were trapped between the Byzantine cavalry to their front and the army to their back and were killed or captured, with a handful making it out of the encirclement. Next, the fortress of Hierakokoryphitis capitulated to John without a fight, along with many other towns and fortifications near Attaleia, after which John returned to Constantinople; the combat at Sozopolis demonstrated the discipline of the Byzantine troops, who could feign flight without panicking. The Byzantine cavalry could fight with both missile and close-combat weapons. John showed himself a competent general, carrying out a complex tactical maneuver at the beginning of his reign

The Lenoir–Rhyne Bears football program is the intercollegiate American football team for Lenoir–Rhyne University located in the U. S. state of North Carolina. The team are members of the South Atlantic Conference. Lenoir–Rhyne's first football team was fielded in 1907; the team plays its home games at the 10,000 seat Moretz Stadium in North Carolina. 1954–1969: NAIA 1970–1992: NAIA Division I 1989–present: NCAA Division II 1907–1930: Independent 1931–1960: North State Conference 1961–1974: Carolinas Conference 1975–present: South Atlantic ConferenceThe Bears had no team from 1912–1920 and 1942–1945. The Bears have participated in five postseason bowl games. Clarence Stasavich has the most victories as coach of the Bears. T. M. Warlick B. H. Shoaf D. M. Williams Phil Utley Norman Lamotte Dick Gurley Robert M. Shores Albert Spurlock Robert M. Shores D. M. Williams Clarence Stasavich Hanley Painter Danny Williams Jack Huss Henry Vansant John Perry Charles Forbes Bill Hart Wayne Hicks Fred Goldsmith Mike Houston Ian Shields Mike Kellar Drew Cronic Mike Jacobs Notable alumni include: Kyle Dugger, 2020 NFL Draft hopeful Perry Fewell, current Defensive Back coach of the Carolina Panthers.

Craig Keith, former tight end for the Pittsburgh Steelers and Jacksonville Jaguars John Milem, former defensive end for the Carolina Panthers and San Francisco 49ers Terence Steward, former wide receiver for the Dallas Cowboys 1939*, 1951, 1952, 1955, 1956, 1958, 1959, 1960, 1961, 1962, 1965, 1966*, 1967, 1975, 1988*, 1994*, 2005, 2006, 2007, 2008, 2009, 2010, 2011*, 2012, 2013*, 2014*, 2015, 2016, 2017, 2018*, 2019* The Bears made three appearances in the NAIA championship game during their tenure, winning in 1960, appeared in the NCAA Division II championship game in 2013. 1939*, 1951, 1952, 1955, 1956, 1958, 1959, 1960, 1961, 1962, 1965, 1966*, 1967, 1975, 1988*, 1994*, 2011*, 2012, 2013, 2014, 2018, 2019 *denotes co-championship. The Bears won 8 titles in the North State Conference, 5 in the Carolinas Conference, 9 in the South Atlantic Conference. Official website