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Greensboro, Alabama

Greensboro is a city in Hale County, United States. At the 2010 census the population was 2,497, down from 2,731 at the 2000 census; the city is the county seat of Hale County, not organized until 1867. It is part of Alabama Metropolitan Statistical Area. Greensboro was incorporated as a town in December 1823 as "Greensborough", it was named in honor of American Revolutionary War general Nathanael Greene. The name was soon simplified to "Greensboro"; the community was known as "Troy" prior to incorporation. Reflecting the history of the antebellum years and a culture built on cotton plantations to produce the commodity crop, several sites on the National Register of Historic Places in or near Greensboro are connected to this past; these include Glencairn, the Greensboro Historic District, Magnolia Grove, the McGehee-Stringfellow House and the Payne House. One hundred years African Americans in Greensboro were among those in the state continuing to work to regain their civil rights after years of second-class status under Jim Crow.

Rev. Martin Luther King Jr. leader of the Southern Christian Leadership Conference, came here in the course of his civil rights projects in the state. In 1968, he hid from Ku Klux Klan members in what is now operated as the Safe House Black Historic Museum. Greensboro is southeast of the center of Hale County and is crossed by Alabama State Routes 14, 25, 69. SR 14 leads east 19 miles to Marion. SR 25 leads northeast through Talladega National Forest 36 miles to Brent and south 32 miles to Thomaston. SR 69 leads southwest 33 miles to Linden. Demopolis is 25 miles to the southwest via SR 69 and U. S. Route 80. According to the U. S. Census Bureau, Greensboro has a total area of 2.4 square miles, of which 0.01 square miles, or 0.40%, are water. The climate in this area is characterized by hot, humid summers and mild to cool winters. According to the Köppen Climate Classification system, Greensboro has a humid subtropical climate, abbreviated "Cfa" on climate maps; as of the census of 2000, there were 2,731 people, 1,026 households, 688 families living in the city.

The population density was 1,146.5 people per square mile. There were 1,142 housing units at an average density of 479.4 per square mile. The racial makeup of the city was 38.30% White, 60.89% Black or African American, 0.04% Native American, 0.77% from two or more races. 0.88% of the population were Hispanic or Latino of any race. There were 1,026 households, of which 32.3% had children under the age of 18 living with them, 35.1% were married couples living together, 27.3% had a female householder with no husband present, 32.9% were non-families. 31.2% of all households were made up of individuals and 14.6% had someone living alone, 65 years of age or older. The average household size was 2.56 and the average family size was 3.21. In the city, the population was spread out with 28.6% under the age of 18, 10.5% from 18 to 24, 20.9% from 25 to 44, 20.5% from 45 to 64, 19.4% who were 65 years of age or older. The median age was 37 years. For every 100 females, there were 86.8 males. For every 100 females age 18 and over, there were 74.6 males.

The median income for a household in the city was $22,930, the median income for a family was $28,990. Males had a median income of $36,071 versus $23,224 for females; the per capita income for the city was $13,271. About 27.2% of families and 35.3% of the population were below the poverty line, including 47.1% of those under age 18 and 26.2% of those age 65 or over. As of the census of 2010, there were 2,497 people, 1,045 households, 629 families living in the city; the population density was 1,040.4 people per square mile. There were 1,195 housing units at an average density of 497.9 per square mile. The racial makeup of the city was 66.5% Black or African American, 32.0% White, 0.2% Native American, 0.6% from two or more races. 0.5 % of the population were Latino of any race. There were 1,045 households, of which 25.6% had children under the age of 18 living with them, 30.4% were married couples living together, 25.2% had a female householder with no husband present, 39.8% were non-families.

37.0% of all households were made up of individuals and 15.9% had someone living alone, 65 years of age or older. The average household size was 2.31 and the average family size was 3.07. In the city, the population was spread out with 24.9% under the age of 18, 7.9% from 18 to 24, 20.5% from 25 to 44, 26.8% from 45 to 64, 19.9% who were 65 years of age or older. The median age was 42 years. For every 100 females, there were 81.1 males. For every 100 females age 18 and over, there were 88.3 males. The median income for a household in the city was $30,082, the median income for a family was $36,379. Males had a median income of $28,869 versus $22,528 for females; the per capita income for the city was $16,277. About 19.0% of families and 23.8% of the population were below the poverty line, including 34.9% of those under age 18 and 23.7% of those age 65 or over. The city of Greensboro has a mayor-council form of government. There is a full-time police force with 13 officers; the city has a volunteer fire department.

Greensboro is served by Greensboro Public School, with two campuses. There is Southern Academy. Anthony Bryant, defensive tackle in the NFL Scott Burton and performance artist Alfred Chapman, Los Angeles real estate attorney and investor, one of the founders of Orange, California John Gayle, seventh governor of the U. S. state of Alabama Am

Théâtre de la Gaîté (boulevard du Temple)

The Théâtre de la Gaîté, a former Parisian theatre company, was founded in 1759 on the boulevard du Temple by the celebrated Parisian fair-grounds showman Jean-Baptiste Nicolet as the Théâtre de Nicolet, ou des Grands Danseurs. The company was invited to perform for the royal court of Louis XV in 1772 and thereafter took the name of Grands-Danseurs du Roi. However, with the fall of the monarchy and the founding of the First French Republic in 1792, the name was changed to the less politically risky Théâtre de la Gaîté; the company's theatre on the boulevard du Temple was replaced in 1764 and 1808, again in 1835 due to a fire. As a result of Haussmann's renovation of Paris, the company relocated to a new theatre on the rue Papin in 1862, the 1835 theatre was subsequently demolished. In 1759 a new Lieutenant General of Police, Antoine de Sartine, took office, Jean-Baptiste Nicolet, an actor who specialized in playing the role of Harlequin, one of the foremost producers of popular entertainments at the Parisian fairs, took the opportunity to obtain permission to begin performing in a rented theatre on the boulevard du Temple, although he continued to present at the fairs until 1789.

The boulevard, 30 meters in width, much greater than a typical Parisian street of the time, ran from the Porte Saint-Martin at the northern edge of the city to the Porte Saint-Antoine in the east. It had been created on top of defensive earthworks erected by Charles V in the 14th century and in 1668, during the reign of Louis XIV, turned into a promenade with four rows of trees. A popular spot, not least because its elevation afforded good views of the windmills of Montmartre and the countryside to the north of the city, it remained unpaved until 1778; the French term boulevard derives from Middle Dutch bolwerc. Nicolet's small boulevard theatre had been put up by Antoine Fouré for the purpose of presenting spectacle mécanique in the manner of Servandoni; the term spectacle mécanique referred to puppet shows, but in this case it more meant a small stage with scenic effects and cut-out flats as moving figures. When Nicolet acquired the use of the theatre he reconstructed it to suit his needs.

One of the major advantages of the new location, besides its popularity, was that performances could be presented year round, rather than intermittently, as was the case at the fairs. Thus Nicolet could begin to compete with the more established theatres in the heart of Paris, he had a license for acrobatics and rope-dancing, but began adding pantomimes and dramatic sketches which were used in the breaks between the other acts. These included incidental music in the form of vaudevilles. Since the pieces with spoken dialogue and singing by the actors fell outside what was permitted by his license, Nicolet sometimes received reminders not to present such works; these admonitions were delivered by the Lieutenant of Police at the instigation of the privileged royal theatres the Comédie-Française, which presented plays in French at their theatre on the rue Neuve-des-Fossés, the Comédie-Italienne, which presented opéras-comiques in French and sometimes opera buffa in Italian at the Hôtel de Bourgogne.

Despite these restrictions, Nicolet's theatre was so successful, that by 1761 he employed 30 actors, 60 dancers, 20 musicians, had a repertoire of around 250 short dramatic pieces. Nicolet's financial success was such that in 1762 he was able to apply for permission to construct a much larger and more substantial theatre, he leased a plot of land located further along the boulevard on the northeast side, away from the city. The site had been part of the moat, filled in, but was still boggy and needed to be drained and leveled before the wooden structure could be built; the new theatre, referred to as the Salle des Grands Danseurs, opened in 1764, was more successful at attracting large audiences, "on Sundays, it was by no means unusual to see a couple of thousand spectators besieging the doors." Rivals during this period were few. One of the most important actors and writers for the Théâtre de Nicolet was Toussaint-Gaspard Taconet. Taconet had started out as a joiner's apprentice but had become a stagehand and prompter at the Opéra-Comique, which at that time was presenting at the Parisian fairs.

He wrote and appeared in several pieces with Nicolet's troupe at the fair theatres, including L'ombre de Vadé at the Foire Saint-Germain in 1757. In 1762 the Opéra-Comique was merged into the Comédie-Italienne and moved into that company's theatre at the Hôtel de Bourgogne; as a result, Taconet joined Nicolet's troupe on the boulevard du Temple. There he wrote a whole series of coarse but hilarious comedy sketches, some of which skirted obscenity, in which he appeared as an actor as a working man a cobbler, a drunkard; the first was Adieux de l'Opéra-Comique. Other titles included L' Impromptu du jour de l'an, L' École villageoise, Le Choix imprévu, Ragotin ou l' arrivée au tripot, Gilles amoureux, L' Homme aux deux femmes, Le Mari prudent et la femme étourdie, his most successful was Les Ecosseuses de la halle, which continued to be presented up to the time of the French Revolution. Taconet became so famous that he acquired the title of Molière des Boulevards. One of his most well-known expressions was "Je te m'éprise comme un verre d'eau".

An obituary in Bachaumont's Mémoires secrets, dated 21 January 1775 shortly after T

Targeted molecular therapy for neuroblastoma

Targeted molecular therapy for neuroblastoma involves treatment aimed at molecular targets that have a unique expression in this form of cancer. Neuroblastoma, the second most common pediatric malignant tumor involves treatment through intensive chemotherapy. A number of molecular targets have been identified for the treatment of high-risk forms of this disease. Aiming treatment in this way provides a more selective way to treat the disease, decreasing the risk for toxicities that are associated with the typical treatment regimen. Treatment using these targets can supplement or replace some of the intensive chemotherapy, used for neuroblastoma; these molecular targets of this disease include GD2, ALK, CD133. GD2 is a target of immunotherapy, is the most developed of these treatment methods, but is associated with toxicities. ALK has more been discovered, drugs in development for this target are proving to be successful in neuroblastoma treatment; the role of CD133 in neuroblastoma has been more discovered and is an effective target for treatment of this disease.

High-risk cases of neuroblastoma are difficult to treat through intensive chemotherapy. For this reason, molecular targets have been identified and are being developed for treatment in patients who have more difficulty responding to treatment. There are a number of genetic factors. In neuroblastoma cells, there can be amplification of genomic DNA regions, loss of genomic DNA regions, genetic abnormalities. All of these factors can contribute to an advanced disease state in high-risk patients. Amplification occurs within a protein called the MYCN oncogene; this protein is amplified in 20% of primary neuroblastoma tumors and is associated with advanced disease state and treatment failure. Loss of genomic regions by deletion can occur at chromosomes 11q. Loss at 1p is correlated with advanced disease state; the loss at 11q is correlated with adverse patient outcomes. Genetic abnormalities occur in a tumor-suppressor gene called caspase 8. Inactivation of this gene will result in tumor cell survival.

Table 1 summarizes the genomic factors used to identify high-risk patients. GD2 is a glycolipid, expressed on the surface of neuroblastoma cells, it is targeted through immunotherapy in neuroblastoma treatment using monoclonal antibodies. These monoclonal antibodies are used to block GD2 expression, are thus referred to as anti-GD2 agents, they can be used for tumor-specific therapy because GD2 expression is weak and limited to certain areas in normal human tissue. Therefore, its expression can be targeted in tumor cells. While anti-GD2 antibodies are effective in clearing the remaining tumors in neuroblastoma patients, there have been major toxicities associated with the use of this form of treatment; these toxicities include neuropathic pain, capillary leak syndrome, hypersensitivity reaction. Anti-GD2 antibodies have been developed for immunotherapy treatment of neuroblastoma and can be grouped into first-generation and second-generation antibodies. First-Generation:14G2a ch14.18 3F8Second-Generation:Hu14.18-IL-2 Hu14.18K332A mAb1A7All of these antibodies are going through clinical trial processes for the treatment of neuroblastoma.

The most extensively studied of these antibodies is ch14.18. Through randomized trials, it has been found that treatment with ch14.18 is most effective when combined with cytokines, such as granulocyte macrophage colony-stimulating factor and interleukin-2. This combination therapy improves the outcome of high-risk neuroblastoma, but does not decrease the risk of toxicities. For this reason, the second-generation antibodies have been developed, which have fewer associated toxicities but are continuing trials to determine their therapeutic efficacy. Mutations in the anaplastic lymphoma kinase oncogene can be inherited and are a major cause of neuroblastoma; these mutations occur in 5-15% of neuroblastoma cases. ALK has been discovered as a molecular target of chemotherapy in the treatment of neuroblastoma patients. Drugs that target ALK are referred to as ALK inhibitors. ALK is expressed on the surface of neuroblastoma tumor cells, making it accessible as a target for cancer treatment. In neuroblastoma patients who do not possess a mutated form of ALK, targeting the non-mutated form of ALK on a tumor cell can be beneficial.

This will cause the tumor to undergo apoptosis, programmed cell death. ALK inhibitors can be used to treat another cause of neuroblastoma referred to as MYCN gene amplification. Amplification of the MYCN protein is a genetic mutation associated with neuroblastoma tumors. MYCN amplification is correlated with a specific mutation in ALK, referred to as the F1174L mutation. ALK inhibitors can suppress the MYCN protein in the tumor cell; the following is a list of ALK inhibitors in clinical trials for treatment of neuroblastoma: Crizotinib CH5424802 ASP3026 Ceritinib AP26113 Crizotinib was the first of these drugs to enter clinical trials and is the sole available ALK inhibitor, approved by the FDA on August 26, 2011. Thus far, it has proven its efficacy in treating adults with non-small-cell lung carcinoma, another form of cancer in which ALK plays a role; the drug is in phase III clinical trials to test its use in treating pediatric cancer types, such as neuroblastoma. CH542802 is in phase I/II trials and is being shown to inhibit the growth of neuroblastoma cells with the amplified expression of ALK.

ASP3026 is in phase I

Jennifer Saret

Jennifer Saret is a Filipino former tennis player. Saret featured in a total of 24 ties for the Philippines Fed Cup team and was a regular medalist for her country at the Southeast Asian Games, debuting in the regional competition as a 14 year old in 1989. Locally, she made her mark by winning four successive PCA Open championships from 1989 to 1992, she was a junior doubles semi-finalist at the 1991 Wimbledon Championships. From 1992 to 1996 she took up a sports scholarship to attend Brigham Young University in the United States, where she played varsity tennis, she was the Western Athletic Conference Player of the Year in 1995. Her Fed Cup career was put on hold while she was at BYU but she returned to the national team in 1997 and made her last appearance in 2001, she retired from Fed Cup tennis with a Philippines record 26 wins. Jennifer Saret at the Women's Tennis Association Jennifer Saret at the Fed Cup Jennifer Saret at the International Tennis Federation

Bathyprion danae

Bathyprion danae, the fangtooth smooth-head, is a species of slickhead found in deep waters of the Atlantic and Pacific Oceans. It is in the monotypic genus Bathyprion. Bathyprion danae is recorded to be found in a marine environment within bathypelagic depth range of about 100 – 3200 meters, they are considered to be a species found in the deep-waters. Bathyprion danae is native to the areas of the Eastern Atlantic, the North Atlantic, the western Pacific, it has been found isolated in the area of Madeira. This species has been recorded to occupy the areas of the European waters, the North West Atlantic, the Portuguese Exclusive Economic Zone, the Spanish Exclusive Economic Zone; the common names of Bathyprion danae in various languages include the following: Fangtooth smooth-head: English Fangtooth smoothhead: English 深海鋸平頭魚: Mandarin Chinese 深海锯平头鱼: Mandarin Chinese The taxonomic classification of Bathyprion danae is as follows: Kingdom: Animalia Phylum: Chordata Subphylum: Vertebrata Superclass: Gnathostomata Class: Actinopterygii Order: Osmeriformes Family: Alepocephalidae Genus: Bathyprion Species: Bathyprion danae Bathyprion danae grows to a length of 38.0 centimetres SL.

Bathyprion danae can be identified by its long, pointed snout. Its upper jaw is longer than its bottom jaw, it reaches out longer than its eye; the scales of this species are colorful and there are numerous small scales on its body. Its body has a brownish color to it. Froese and Pauly, eds.. "Bathyprion danae" in FishBase. February 2012 version

Dodamarg taluka

Dodamarg taluka is a taluka in Sindhudurg district in the Indian state of Maharashtra. Dodamarg Taluka is situated between latitudes 15° 37' N and 15° 60' north and longitudes 73° 19' E and 73° 40' east, it is bordered by the Goa state to the south and west, Karnataka to the southeast and Sahyadri range to the east with a total area of 45053 hectares. Dodamarg is the smallest taluka in Sindhudurg district. According to the census of 2001, the taluka has 53 villages. Both Marathi and Malwani are spoken. Marathi is, the official language of the Dodamarg. Sex ratio in Dodamarg is 1054 i.e. for each 1000 males, below national average of 940 as per census 2011. Literacy rate in Dodamarg is 76.3%. Population of Dodamarg taluka is 50,032 persons as per latest provisional figures released by directorate of census operation in Sindhudurg, which shows a decrease of 2.30 percent in 2011 compared to figures of 2001 census. Dodamarg is a hilly region surrounded by mountains; the main rivers flowing across the taluka is Tilari.

Tilari dam is constructed on this river. Kalne river is one of the tributary of this river. There is a village named Mangeli at the eastern end Dodamarg taluka as well as on the border of Karnataka state. There are viewing points at Unneyi Bandharam, inter-state project of Tilari Dam, Rock Garden, the fort of Pargad and Hunumant Gad, Tervan Medhe, Kasainath Hill, Devotional places of faith like Nagnath Temple and elsewhere; the interstate dam project taken up under the auspices of Irrigation Dept. of Goa and Maharashtra State Govt. The Dam is constructed on Tilari river in Dodamarg Taluka. There is a large reservoir formed by the Tilari Dam. Now-a-days, a number of wild elephants take shelter in the surroundings of Tilari; the dam and the lake at the distance of 45 km from Goa State, attract tourists as well as observers. The Wirdi fall in Dodamarg Taluka is so far an untouched site, at the distance of 20 km from Dodamarg Taluka place. For the last 10 to 15 years, people from Kerala have done deep study of land and environment of this area and started plantation of Pineapples along with Banana.

Now pineapple is one of the main products of taluka. Recent years elephants are marking entry into Dodamarg taluka from Karnataka state through Khanapur jungle; this is the first time, elephants have found habitation in Maharashtra State. Tilari major irrigation project area is the main habitat. People of dodamarg Also planting the pineapple and banana and sell it to the Mumbai or local market including North Goa The Pargad Fort was built by Shivaji in 1674 to 1676 AD, on adjoining borders of Kolhapur and Sindhudurg Districts. Structurally it looks like a conch-shell; the fort was suitable to keep watch on the movement of the enemy in Goa as well as Konkan. Vijghar 66 MW power house Tilari Dam Pargadh - Fort Mangeli Water Fall Kasainath Mountain Nagnath Temple Medhe Virdi Water Fall Virdi Dam Talkat Garden Sasoli caves Mahalaxmi Power project konalkatta Parme river Shri Shantadurga Mandir Daloba Mandir Sateri Purmar Mandir Damodar Temple Sateri Kelbai Temple Kasai Dodamarg Rastroli Siddheshwar Temple Dhatwadi Kasai Dodamarg Ganesh temple Dodamarg Hanuman Mandir Dodamarg Rashtroli Datt Mandir sawantwada Dodamarg Pimpaleshwar Dodamarg Kasainath Mountain Dodamarg Saibaba Mandir Dhatwadi Dodamarg Nagnath Mandir Medhe Parme Sateri Devi Mandir Shri Sateri Bhutnath Temple,Sonawal Shri Sateri Devi Mandir, MangeliHanumanth gadh, Fukeri.

Shri. Devi Mauli Temple, Fukeri. Dodamarg Darshan