Greenville University is a private university in Greenville, Illinois. It is affiliated with the Free Methodist Church. Established as Greenville College in 1892, the institution was renamed Greenville University in 2017.

Greenville is a city in Bond County, Illinois, United States, 51 miles (82 km) east of St. Louis. The population as of the 2020 census was 7,083, up from 7,000 at the 2010 census. It is the county seat of Bond County.