Greer is a city in Greenville and Spartanburg counties in the U.S. state of South Carolina. The population was 35,308 as of the 2020 census, making it the 14th-most populous city in South Carolina. Greer is included in the Greenville-Anderson-Greer, SC Metropolitan Statistical Area, which is part of the Greenville-Spartanburg-Anderson, SC Combined Statistical Area in Upstate South Carolina.

Greenville County is located in the U.S. state of South Carolina. As of the 2020 census, the population was 525,534, making it the most populous county in the state. Its county seat is Greenville. The county is also home to the Greenville County School District, the largest school system in South Carolina.