Grenfell Street is a major street in the north-east quarter of the Adelaide city centre, South Australia. The street runs west-east from King William Street to East Terrace. Its intersection with Pulteney Street is formed by Hindmarsh Square. On the west side of King William Street, it continues as Currie Street towards West Terrace.

Adelaide city centre is the inner city locality of Greater Adelaide, the capital city of South Australia. It is known by locals simply as "the City" or "Town" to distinguish it from Greater Adelaide and from the City of Adelaide local government area. The population was 15,115 in the 2016 census.