Grigore Alexandru Ghica or Ghika was a Prince of Moldavia between 14 October 1849, and June 1853, and again between 30 October 1854, and 3 June 1856. His wife was Helena, a member of the Sturdza family and daughter of Ioan Sturdza, who had been Prince of Moldavia from 1822 to 1828.

The House of Ghica [or Ghika] was a noble family whose members held significant positions in Wallachia, Moldavia and later in the Kingdom of Romania, between the 17th and 19th centuries. The Ghica family produced many voivodes of Wallachia and Moldavia and two Prime Ministers of Romania. Several branches of the family still exist today.