Grodno Governorate was an administrative-territorial unit (guberniya) of the Northwestern Krai of the Russian Empire, with its capital in Grodno. It encompassed 38,671.5 square kilometres (14,931.1 sq mi) in area and consisted of a population of 1,631,645 inhabitants by 1897. Grodno Governorate bordered by Suwałki Governorate to the north, Vilna Governorate to the northeast, Minsk Governorate to the east, Volhynia Governorate to the south, Kholm Governorate to the west, and Łomża Governorate to the northwest. The governorate covered the areas of modern-day Grodno Region of Belarus, part of the Podlaskie Voivodeship of Poland, and a small part of Druskininkai, Lazdijai and Varėna districts of Lithuania.

Grodno Region or Hrodna Region, also known as Grodno Oblast or Hrodna Voblasts, is one of the regions of Belarus. Its administrative center, Grodno, is the largest city in the region. As of 2024, it has a population of 992,556.