Grootfontein is a city with 26,839 inhabitants in the Otjozondjupa Region of central Namibia. It is one of the three towns in the Otavi Triangle, situated on the B8 national road that leads from Otavi to the Caprivi Strip.

Otjozondjupa is one of the fourteen regions of Namibia. Its capital is Otjiwarongo. The region further contains the municipalities of Okahandja and Grootfontein and the towns Okakarara and Otavi. As of 2020, Otjozondjupa had 97,945 registered voters.