Grote Prijs Jef Scherens is a single-day road bicycle race held annually in September in Leuven, Belgium. Since 2005, the race is organized as a 1.1 event on the UCI Europe Tour. The race is named after the seven-time professional sprint world champion Jef Scherens.

Leuven or Louvain is the capital and largest city of the province of Flemish Brabant in the Flemish Region of Belgium. It is located about 25 kilometres east of Brussels. The municipality itself comprises the sub-municipalities of Heverlee, Kessel-Lo, Leuven proper, Wilsele, Wijgmaal and part of Haasrode and Korbeek-Lo. It is the eighth largest city in Belgium, with more than 100,244 inhabitants.