Groton-Dunstable Regional High School (GDRHS) is a high school located in Groton, Massachusetts, United States, and serves the communities of Groton and Dunstable in the Groton-Dunstable Regional School District. While GDRHS is the only public high school located within those communities students from Groton may also attend the public Nashoba Valley Technical High School and students from Dunstable may attend the public Greater Lowell Technical High School. Approximately 810 students attend GDRHS and they are primarily graduates of Groton-Dunstable Regional Middle School. GDRHS has a primarily college preparatory curriculum, with approximately 87% of its students attending four-year colleges and over 90% attending two- or four-year colleges upon graduation in 2010.

Groton is a town in northwestern Middlesex County, Massachusetts, United States, within the Greater Boston metropolitan area. The population was 11,315 at the 2020 census. An affluent bedroom community roughly 45 miles from Boston, Groton has a large population of professional workers, many of whom work in Boston's tech industry. It is loosely connected to Boston by highways and commuter rail.