Grymes Hill is a 374 feet (114 m) tall hill formed of serpentine rock on Staten Island, New York. It is the second highest natural point on the island and in the five boroughs of New York City. The neighborhood of the same name encompasses an area of 0.894 square miles (2.32 km2) and has a population of 8,263 people. The hill also includes parts of the Silver Lake neighborhood. The area includes part of ZIP Codes 10301 and 10304.

John Randolph Grymes was a New Orleans attorney, member of the Louisiana state legislature, U.S. attorney for Louisiana district, and aide-de-camp to General Andrew Jackson during the Battle of New Orleans.