The Guadiana class was a class of four destroyers employed by the Portuguese Navy between 1913 and 1942. This class is often alternatively referred as the Douro class.

The Douro class destroyers consisted of five ships used by the Portuguese Navy and two used by the Colombian Navy, all built during the 1930s. Note that in Portugal, this class of destroyers is usually referred to as the Vouga class, with the term Douro class being usually employed to designate the previous class of Portuguese destroyers also known as Guadiana class.